Dendritic voltage-gated K conductance gradient in pyramidal neurones of neocortical layer 5B
نویسندگان
چکیده
published online Dec 21, 2006; J. Physiol. Almog, Hana Ben-Porat, Bert Sakmann and Alon Korngreen Andreas T Schaefer, Moritz Helmstaedter, Arno C Schmitt, Dan Bar-Yehuda, Mara neocortical layer 5B Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of Physiology in Press This information is current as of September 18, 2007 http://jp.physoc.org/cgi/content/abstract/jphysiol.2006.122564v3 The latest version of this article is at:
منابع مشابه
Dendritic voltage-gated K+ conductance gradient in pyramidal neurones of neocortical layer 5B from rats.
Voltage-gated potassium channels effectively regulate dendritic excitability in neurones. It has been suggested that in the distal apical dendrite of layer 5B (L5B) neocortical pyramidal neurones, K+ conductances participate in active dendritic synaptic integration and control regenerative dendritic potentials. The ionic mechanism for triggering these regenerative potentials has yet to be eluci...
متن کاملVoltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients.
We investigated the types and distribution of voltage-gated K+ channels in the soma and apical dendrite of layer 5 (L5) neocortical pyramidal neurones, of young rats (postnatal days 13-15), in acute brain slices. A slow inactivating outward K+ current and a fast inactivating outward K+ current were detected in nucleated patches. The slow K+ current was completely blocked by tetraethylammonium (...
متن کاملDistribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons.
The apical tuft is the most remote area of the dendritic tree of neocortical pyramidal neurons. Despite its distal location, the apical dendritic tuft of layer 5 pyramidal neurons receives substantial excitatory synaptic drive and actively processes corticocortical input during behavior. The properties of the voltage-activated ion channels that regulate synaptic integration in tuft dendrites ha...
متن کاملA quantitative description of dendritic conductances and its application to dendritic excitation in layer 5 pyramidal neurons.
Postsynaptic integration is a complex function of passive membrane properties and nonlinear activation of voltage-gated channels. Some cortical neurons express many voltage-gated channels, with each displaying heterogeneous dendritic conductance gradients. This complexity has hindered the construction of experimentally based mechanistic models of cortical neurons. Here we show that it is possib...
متن کاملCorrection of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels.
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential. In voltage-clamp experiments, incomplete space clamp distorts the recorded currents, rendering accurate analysis impossible. Here, we present a simple numerical algorithm that c...
متن کامل